A Dangerous Transition | Anne Weston

Just as embryonic cells undergo an epithelial to mesenchymal transition during gastrulation, cancer cells can reactivate this developmental program to become motile and metastasize to other tissues. During this “EMT,” adherens junction components, such as E-cadherin and β-catenin, are targeted for destruction, while the activation of the GTPases Cdc42 and Rac1 favors the formation of lamellipodia and filopodia, migration, and invasion.

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    A Dangerous Transition | Anne Weston Just as embryonic cells undergo an epithelial to mesenchymal transition during...
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